CV

Statistical and machine learning methods for single-cell, spatial, and sequence data. Updated October 2026.

General Information

Full Name Zhen Miao
Email zmiao2@fredhutch.org
Affiliation Fred Hutch Cancer Center and Howard Hughes Medical Institute
Publications Google Scholar

Academic Appointments

  • 2026–present
    Postdoctoral Researcher
    Fred Hutch Cancer Center and Howard Hughes Medical Institute
    • February 2026–present. Advisor: Erick Matsen.
    • Models combining antibody sequence transformers with explicit mutation, codon-preference, and amino-acid selection components.
  • 2024–2025
    Postdoctoral Researcher
    University of Pennsylvania
    • December 2024–December 2025. Advisors: Junhyong Kim and Nancy Zhang.
    • Developed CoPro to identify coordinated progression of cell states in spatial transcriptomics.

Education

  • 2024
    PhD in Genomics and Computational Biology
    University of Pennsylvania
    • Completed December 2024. Advisor: Junhyong Kim.
    • Thesis: Statistical foundations of single cell open chromatin assays.
  • 2024
    MA in Statistics and Data Science
    University of Pennsylvania
    • Completed May 2024. Advisor: Nancy Zhang.
    • Thesis: Charting the coordinated progression of cell states in spatial transcriptomic data.
  • 2019
    BS in Biological Sciences
    Nankai University
    • Minor in Applied Mathematics.

Research Interests

  • Spatial transcriptomics and single-cell multiomics
    • Modeling coordinated cell-state changes across cell types and tissue sections.
    • Integrating single-cell multiomics to study cellular regulation and tissue organization.
  • Single-cell epigenomics
    • Separating latent chromatin accessibility from assay measurement and capture processes.
    • Testing the effects of multiple biological factors on chromatin accessibility.
  • Biological sequences
    • Combining language models with mechanistic models of B-cell receptor evolution.
    • Distinguishing mutation, codon preference, and amino-acid selection.

Research Software

  • CoPro
  • PACS
    • Depth-corrected multifactor testing of chromatin accessibility in scATAC-seq.
  • PIC
    • Corrects insertion-counting artifacts in single-nucleus ATAC-seq quantification.

Teaching and Mentoring

  • 2024
    Guest Lecturer
    University of Pennsylvania
    • STAT-9915: Advanced Topics in Biomedical Data Science.
    • Lectured on statistical methods for single-cell chromatin accessibility, including PIC and PACS.
  • 2021–2024
    Graduate Teaching Assistant
    University of Pennsylvania
    • BIOM/CIS/MTR-5350: Introduction to Bioinformatics.
    • GCB-5330: Statistics for Genomics and Biomedical Informatics.
    • Held weekly office hours, developed course materials, and supported students with statistical and computational analyses.
  • 2024
    Research Mentoring
    • Kernyu Park, research assistant: benchmarking statistical tests for scATAC-seq data.
    • Elena Theus, undergraduate student: visualization tools for single-cell multiomics.

Honors and Awards

  • 2026
    Third Place Poster Award
    American Statistical Association, Section on Statistics in Genomics and Genetics
  • 2025
    University of Pennsylvania Nominee for the Regeneron Prize for Creative Innovation
    • Selected as Penn's sole predoctoral nominee.
  • 2024
    NIH-CZI Junior Atlas Builder Travel Grant
  • 2022–2023
    Blavatnik Family Fellowship in Biomedical Research
    University of Pennsylvania
    • One of six recipients across Penn Medicine PhD candidates.
  • 2019
    Semifinalist, Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research
    American Society of Human Genetics
  • 2019
    ACGA Trainee Award
    • Awarded to the top three predoctoral students' platform presentations.
  • 2019
    Outstanding Graduate
    Nankai University
  • 2017, 2019
    National Scholarship
  • 2018
    Poling Scholarship
    Nankai University
    • Awarded to ten students in the Poling Program for academic performance.
  • 2017
    First Place, Fifth Life Sciences Students' Experimental Skills Competition in Tianjin

Selected Presentations

  • 2026
    • ASA Section on Statistics in Genomics and Genetics meeting, lightning talk: Modeling coordinated progression in spatial transcriptomics with CoPro.
  • 2024
    • ASA Section on Statistics in Genomics and Genetics meeting, platform presentation: Model-based compound hypothesis testing for snATAC-seq data with PACS.
  • 2023
    • Cold Spring Harbor Laboratory Single Cell Analyses meeting, platform presentation: Model-based compound hypothesis testing for snATAC-seq data with PACS.
    • NIH Junior Atlas Builder meeting, lightning talk: Atlas-scale integrative analysis of snATAC-seq data with PACS.
  • 2021
    • ReBuilding a Kidney semiannual meeting: Best practices of quantification for single cell epigenomics data.
    • Penn IRM Stem Cell Club: Charting kidney development through single cell multiomics study.
  • 2019
    • ASHG annual meeting, platform presentation: Characterizing cellular communication in the human brain by single-cell RNA-seq.
    • MidAtlantic Bioinformatics Conference, lightning talk: Charting cellular communication network in Alzheimer’s Disease.

Service

  • 2021–2023
    GCB Advising Committee
    University of Pennsylvania
    • Advised first-year PhD students on course selection and helped second-year students prepare for candidacy exams.
  • Journal and Conference Reviewer
    • Nature Machine Intelligence, Genome Biology, PLOS Computational Biology, Communications Biology, ISMB, ICLR, and other journals and conferences.

Industry Experience

  • 2022
    Graduate Student Intern, Computational Biology
    23andMe
    • June–August 2022. Supervisor: Robert Tunney.
    • Optimized parallel computation and data handling in TACTICAL and extended the framework to single-cell ATAC-seq data.