CV
Statistical and machine learning methods for single-cell, spatial, and sequence data. Updated October 2026.
General Information
| Full Name | Zhen Miao |
| zmiao2@fredhutch.org | |
| Affiliation | Fred Hutch Cancer Center and Howard Hughes Medical Institute |
| Publications | Google Scholar |
Academic Appointments
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2026–present Postdoctoral Researcher
Fred Hutch Cancer Center and Howard Hughes Medical Institute - February 2026–present. Advisor: Erick Matsen.
- Models combining antibody sequence transformers with explicit mutation, codon-preference, and amino-acid selection components.
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2024–2025 Postdoctoral Researcher
University of Pennsylvania - December 2024–December 2025. Advisors: Junhyong Kim and Nancy Zhang.
- Developed CoPro to identify coordinated progression of cell states in spatial transcriptomics.
Education
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2024 PhD in Genomics and Computational Biology
University of Pennsylvania - Completed December 2024. Advisor: Junhyong Kim.
- Thesis: Statistical foundations of single cell open chromatin assays.
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2024 MA in Statistics and Data Science
University of Pennsylvania - Completed May 2024. Advisor: Nancy Zhang.
- Thesis: Charting the coordinated progression of cell states in spatial transcriptomic data.
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2019 BS in Biological Sciences
Nankai University - Minor in Applied Mathematics.
Research Interests
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Spatial transcriptomics and single-cell multiomics
- Modeling coordinated cell-state changes across cell types and tissue sections.
- Integrating single-cell multiomics to study cellular regulation and tissue organization.
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Single-cell epigenomics
- Separating latent chromatin accessibility from assay measurement and capture processes.
- Testing the effects of multiple biological factors on chromatin accessibility.
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Biological sequences
- Combining language models with mechanistic models of B-cell receptor evolution.
- Distinguishing mutation, codon preference, and amino-acid selection.
Research Software
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CoPro
- Detects coordinated cell-state progression in spatial transcriptomics.
- Python implementation.
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PACS
- Depth-corrected multifactor testing of chromatin accessibility in scATAC-seq.
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PIC
- Corrects insertion-counting artifacts in single-nucleus ATAC-seq quantification.
Teaching and Mentoring
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2024 Guest Lecturer
University of Pennsylvania - STAT-9915: Advanced Topics in Biomedical Data Science.
- Lectured on statistical methods for single-cell chromatin accessibility, including PIC and PACS.
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2021–2024 Graduate Teaching Assistant
University of Pennsylvania - BIOM/CIS/MTR-5350: Introduction to Bioinformatics.
- GCB-5330: Statistics for Genomics and Biomedical Informatics.
- Held weekly office hours, developed course materials, and supported students with statistical and computational analyses.
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2024 Research Mentoring
- Kernyu Park, research assistant: benchmarking statistical tests for scATAC-seq data.
- Elena Theus, undergraduate student: visualization tools for single-cell multiomics.
Honors and Awards
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2026 Third Place Poster Award
American Statistical Association, Section on Statistics in Genomics and Genetics -
2025 University of Pennsylvania Nominee for the Regeneron Prize for Creative Innovation
- Selected as Penn's sole predoctoral nominee.
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2024 NIH-CZI Junior Atlas Builder Travel Grant
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2022–2023 Blavatnik Family Fellowship in Biomedical Research
University of Pennsylvania - One of six recipients across Penn Medicine PhD candidates.
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2019 Semifinalist, Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research
American Society of Human Genetics -
2019 ACGA Trainee Award
- Awarded to the top three predoctoral students' platform presentations.
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2019 Outstanding Graduate
Nankai University -
2017, 2019 National Scholarship
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2018 Poling Scholarship
Nankai University - Awarded to ten students in the Poling Program for academic performance.
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2017 First Place, Fifth Life Sciences Students' Experimental Skills Competition in Tianjin
Selected Presentations
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2026 - ASA Section on Statistics in Genomics and Genetics meeting, lightning talk: Modeling coordinated progression in spatial transcriptomics with CoPro.
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2024 - ASA Section on Statistics in Genomics and Genetics meeting, platform presentation: Model-based compound hypothesis testing for snATAC-seq data with PACS.
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2023 - Cold Spring Harbor Laboratory Single Cell Analyses meeting, platform presentation: Model-based compound hypothesis testing for snATAC-seq data with PACS.
- NIH Junior Atlas Builder meeting, lightning talk: Atlas-scale integrative analysis of snATAC-seq data with PACS.
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2021 - ReBuilding a Kidney semiannual meeting: Best practices of quantification for single cell epigenomics data.
- Penn IRM Stem Cell Club: Charting kidney development through single cell multiomics study.
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2019 - ASHG annual meeting, platform presentation: Characterizing cellular communication in the human brain by single-cell RNA-seq.
- MidAtlantic Bioinformatics Conference, lightning talk: Charting cellular communication network in Alzheimer’s Disease.
Service
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2021–2023 GCB Advising Committee
University of Pennsylvania - Advised first-year PhD students on course selection and helped second-year students prepare for candidacy exams.
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Journal and Conference Reviewer
- Nature Machine Intelligence, Genome Biology, PLOS Computational Biology, Communications Biology, ISMB, ICLR, and other journals and conferences.
Industry Experience
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2022 Graduate Student Intern, Computational Biology
23andMe - June–August 2022. Supervisor: Robert Tunney.
- Optimized parallel computation and data handling in TACTICAL and extended the framework to single-cell ATAC-seq data.